Socket Preservation, using deprotenized bovine bone matrix with and without plasma rich in growth factors(a cannine study)

Abstract

The accelerating effect of plasma rich in growth factors in the healing of extraction sockets has been shown by some studies. The aim of the present investigation was to evaluate the effect of deproteinizd bovine bone matrix (DBBM) with and without plasma rich in growth factors (PRGF) in canine extraction socket. Methods: Distal root of the second and third upper premolars were extracted bilaterally in six mongrel dogs. Buccolingual (BL) and appico-coronal (AC) dimensions of extraction socket were measured. The extraction sockets were randomly grafted with DBBM+PRGF or DBBM. The ungrafted extraction sockets were allowed to be filled with clot that was served as control. The dogs were sacrificed after 3 months and the extraction socket were evaluated from both clinical and histological view of point. Results: There were significant differences in post extraction vertical dimensions of the sockets among the study groups. The mean AC changes were 6.252.13 mm, 6.831.83 mm, and 3.831.63 mm in DBBM, BDDM+PRGF, and control group respectively (P=0.034). The mean BL dimension reduction in both DBBM+PRGF and DBBM groups was 2.001.09 mm, whereas this amount was 2.661.47 mm in control group (P=0.627). The greatest amount of bone resorption was occurred in control group whereas the PRGF group showed the least amount of bone resorption. Control group expressed a complete bone fill and the bone formation rate which was more apparent than the experimental groups. Conclusions: The findings of this study indicate that using of DBBM with and without PRGF may successfully maintain the socket dimensions.