Investigation of association between different types of oral lichen plan with lipid profile

Abstract

Lichen planus is a chronic inflammatory skin-mucous illness. Although the etiology of this illness is still unknown but some researches indicated that the immunity system can be one of the reasons which may cause it to appear. Initializing the illness, activity of T lymphocytes in auto-immune process, increasing the dilatory sensitivity and releasing of inflammatory cytokine against self-cells can be affective. Whereas, the connection of TCR to MHC of anti-gene presenting cells (APC) is necessary in order to activating the T lymphocytes and on the other hand according to the necessity of lipids in order to transmitting the signals into T lymphocytes, it is reasonable to consider lipids as the illness agent. while, the relation of oral lichen planus and lipid profile has not been investigate so far, in this study the relation of non-erosive and erosive oral lichen plan species with the amount of the tri-glyceride (TG), cholesterol (CH) , low density lipid (LDL) and high density lipid (HDL) is elucidated in Iranian society. Materials and Methods: In this study 22 people stricken with erosive oral lichen planus and 22 other stricken with non-erosive oral lichen planus were investigated among those referred to oral disease department of Dentistry University. Furthermore 44 healthy people were investigated as instance cases. In this study Manova test with SPSS.15 software was used (p<0.05). Results: In lichen planus group the amount of tri-glyceride( TG) and cholesterol (CH) were reasonably more than instance group which was same for erosive group in comparison with non-erosive group( The amount of P for TG=0.014 and for CH 0.012). The amounts of HDL and LDL between lichen planus and instance groups were not meaningfully different. Discussion: In the group of oral lichen planus patients increasing of tri-glyceride (TG) and cholesterol (CH) was seen which can indicates the relation between the amounts of these two criteria with oral lichen planus.