Evaluation the level of phospholipase A2 IIa in oral reactive lesions

Abstract

Oral reactive lesions are the most common oral cavity lesions that represent a reactive hyperplasia of connective tissue in response to local stimulations. Phospholipase A2 plays an important role in the hyperplasia with change in cells functions, such as altering receptor activity, signaling or activation of transcription factors, and the production of lipid mediators such as prostaglandins and leukotrienes. The aim of this study was to investigate the level of phospholipase A2 IIa (sPLA2 IIa) in the healthy marginal and reactive oral tissues.Methods: Marginal healthy and reactive tissues from 27 patients were included in this study. Paired samples collected from each patient. The level of sPLA2 IIa was determined in tissue extracts by ELISA and the obtained results was compared in reactive lesions and marginal tissues.Results: There were significant differences between the level of sPLA2 (p = 0.02, t= 0.43) in the reactive and marginal tissues. The levels of sPLA2 (1.84 times) was elevated in the reactive lesions. Also there was significant differences between the level of sPLA2 in marginal tissues and lesions location (p=0.02) and lesion types (p=0.02).Conclusion: The level of sPLA2 IIa increased in oral reactive tissues. According to these findings, observed changes in the level of sPLA2 IIa plays an important role in pathology of oral reactive lesions.