Evaluation of lasertherapy effect in prevention of oral mucositis induced by chemoradiation

Abstract

Chemotherapy-induced oral mucositis (COM) is a common, debilitating complication of cancer therapy. The aim of this study is to determine the effect of Low level laser therapy employed to prevent oral Mucositis resulting from chemoradiation . METHODS:The patients with healthy oral mucosa receiving radiotherapy and chemotherapy for their oral cavity and salivary glands randomly divided in two groups of 23 individuals. Both groups of chemoradiation regimen hadcisplatin in a dose of 30 mg/m2 every week (intravenous infusion), and 4-5 hours before or after that, radiotherapy with daily administration of 180- 200CGY, 5 days a week carried out. All the patients rested for 2 days (conventional method). All selected patients received radiotherapy for their oral cavity and salivary glands. They received chemotherapy in combination with radiation at the same day for 5 successive days with wave length of 630 nanometers, power of 30 mw and dose of 5 j/cm2. The LLLT was targeted, 10 spots about 8mm in diameter in oral cavity. In the laser off group, laser therapy with off device was done.The patients in both groups examined by the researcher every other day for 30 days, and the required information gathered in data collection forms. At the end of the treatment, the degree of oral mucositis,xerostomia and the patientsE satisfaction wereanalyzed by (QLQ-C30) criteria. RESULTS