Evaluation of Hypozalix artificial saliva and propolis mouthwash efficiency for the preventation of Chemotherapy induced - oral mucositis in Leukemia patients

Abstract

Oral mucositis is among the complications of head and neck chemotherapy. The current study was conducted to evaluation of Hypozalix artificial saliva and propolis mouthwash efficiency for the prevention of Chemotherapy induced-oral mucositis in Leukemia patients . Materials & Methods: This was a randomized controlled clinical trial conducted on 72 Chemotherapy induced-oral mucositis in Leukemia patients. The patients were assigned into 3 equal treatment groups: Hypozalix artificial salivary, Propolis Mothwash, and control groups. The method of artificial saliva Hypozalix usage according to the manufacturer order was as 4 or 5 puffs every 8 hours and every time on the left or right buccal mucosa ,and the second group method usage was for 14 days, everyday 3 times, each time 10CC of propolis mouthwash rinse for one minute in the mouth and then back out. Results: according to the results, the grade of mucositis for propolis group was significantly lower than control group (P<0.005);and the improvement in the severity of the mucositis was higher in propolis group than Hypozalix group(P<0.005). Discussion & Conclusions: generally the results showed that both of the drugs were efficient and could be improve the quality of life has been linked to oral health. Effectiveness of the propolis was more than the artificial saliva in reducing the severity of mucositis.