Effect of non-surgical periodontal treatment with or without combination of Amoxicilin-Metronidazole in type II diabetic patients with chronic periodontitis

Abstract

Periodontal disease is a prevelant in diabetics. Not only diabetes is a risk in the development of periodontal disease, but olso this disease affect the glycemic control in diabetics. Therefore, this study aimed to evaluate the influence of nonsurgical periodontal treatment with and without administration of amoxicillin and metronidazole in type II diabetics with chronic periodontitis. Materials & Methods: In this randomized clinical trial, 60 type II diabetic patients with chronic periodontitis were selected according to inclusion criteria and randomly divided into two groups. In one group the patients were treated with scaling and root planning with administration of amoxicillin and metronidazole and at the other group the scaing and root planning alone (control) were carried out. The pocket depth, loss of attachment, bleeding on probing and HbA1C indices were measured before and 1 & 3 months after treatment to observe the periodontal healing and glycemic control. The collected data were analysed using Spss 16 statistical software. Results: In both control and test groups pocket depth, loss of attachment, bleeding reduced after treatment. The indices improvement were better in test group rather than control one, but this difference was only significant in pocket depth at 3-month interval (P<0.05). The reduction in HbA1C levels was observed in both groups and there was more reduction in test group (P<0.05). Conclusions: With both treatment modilites, the periodontal healing and glycemic control enhancement were observed. The comparison of the groups revealed that the results were better in nonsurgical treatment with administrasion of amoxicillin and metronidazole.