Effect of Beta-Blocker on healing of dental socket following maxillary right first molar extraction in wistar rats

Abstract

This study aimed at evaluating the effect of 2-adrenergic receptor antagonists on number of osteoclasts and osteoblasts involved in the healing of extraction socket of maxillary first molar in rats. Materials and Methods: Maxillary first molars of 40 rats were extracted and divided into 2 groups of test and control. The test group received 0.1 mg/kg injection intraperitoneally daily for the whole study period. The control group received same amount of normal saline through a similar procedure. At days 7, 14, 21 and 28 post-extraction 5 rats were euthanized from each group. Maxillary bone was resected and after sectioning for histological examination, mean number of osteoblasts and osteoclasts in tooth socket was measured in respective days. Results: At week one following extraction number of osteoclasts in the control group was significantly higher than the group receiving propranolol. Also, a significant increase in the number of osteoclasts in both groups at week 1 was observed compared to the following weeks (P<0.05). Number of osteoblasts in the control group at week 2 reached to its maximum rate but stayed constant in the 3rd and 4th weeks. Number of osteoblasts in the test group increased similar to the control group but reached to its maximum rate at week 3 and showed a significant increase compared to the control group (P<0.05). Conclusion: 2 adrenergic receptor antagonists decrease the number of osteoclasts and increase the number of osteoblasts during extraction socket healing.