configuring the WT1 gene expression in oral squamous cell carcinoma and itits relationship between histopathologic aspects

Abstract

The most common oral cancer is Squamous Cell Carcinoma (SCC) that a wide variety of environmental effects has caused complex etiology in terms of prevalence show. In a normal body WT1 gene product is, WT1 protein which is expressed in the kidneys, gonads, urinary tract, decidua, skeletal muscle, mesothelium, muscles, bladder. Also a significant correlation between the levels of WT1 expression and prognosis of the disease has been reported.Materials and Methods: For This descriptive - analytical study samples were collected from 45 patients from the archives of Pathology Department of Imam Reza Hospital Tabriz and Department of Pathology of Dentistry School. In this study, data from patients' records and results of immunohistochemical staining (IHC) were collected in the laboratory . After a review of the histopathologic grade we compared them with the data records to ensure the accuracy grade and then Were compared with the results of immunohistochemistry. Chi-square test and comparison of independent groups were analyzed using statistical software spss16.Results: The average age of the participants in our study have been obtained (66.42±16.06) years.overally we had 45 participants which 16 were female with equivalenve of (35.6%) female and 29 cases of 64.6 percent were males. 36 cases with equalivalance of(80%) were in the histopathologic grade of well-differentiated 2 poorly-differentiated grade equivalent to (4/4 %)and 7 moderate equivalent to (6/15%) was reported.in this study expression of WT1 has been reported as (6.2%).all cases with expression of WT1 were in histopatologic grade if well-differentiated.Conclusion: Further studies in this area for investigating the possibility of treatment with immunotherapy based WT1 peptide as an effective treatment in cases with increased expression of WT1 are suggested.