Comparison of the effect of 3 Mixtatin and MTA(Mineral Trioxide Aggregate) in direct pulp capping of primary molar teeth (A randomized control clinical trial

Abstract

This study aimed to examine the efficacy of 3Mixtatin (a combination of simvastatin and 3Mix antibiotic) as a novel pulp capping biomaterial in direct pulp capping (DPC) of human primary molars. Materials and Methods .In this randomized clinical trial, 160 primary molars from 83 healthy children aged 3-6 years were randomly allocated into four groups. Small traumatic non-caries pulpal exposures were treated by DPC using simvastatin, 3Mix, 3Mixtatin or MTA. Capping materials were covered with hard setting zinc oxide-eugenol (ZOE) cement and then teeth were restored with amalgam. Clinical and radiographic examinations were conducted at 2, 6 and 12 months after treatment. The data were compared using chi-square test at a significance level of 0.05. Results .One hundred and twenty nine teeth were available for follow-up study. By the end of 12 months, the overall success rates were 93.8% in MTA, 91.9% in 3Mixtatin, 62.5% in 3Mix and 57.1% in simvastatin groups. No statistically significant difference was found between the outcomes of MTA and 3Mixtatin groups (P>0.05). 3Mixtatin had statistically superior results compared to 3Mix and simvastatin (P<0.01). Conclusion .Radiographic and clinical outcomes in 3Mixtatin group could suggest it as an acceptable alternative in DPC of primary molar teeth.