Comparison of serum autoantibadies to desmogleins I,III in patient with oral lichen planus and normal group

Abstract

Lichen planus is a relatively common mucocutaneus disease that oral lesions are seen in 30-70 percent of patients and known as premalignant lesion, with unknown etiology. One of research field that limiting researches were performed on this field is investigation of serum autoantibodies to desmogleins 1, 3. In this research with investigation of these factors we attempted to reveal causal etiology of this disease. Materials and methods: Serum concentrations of circulating autoantibodies to Dsg1 and Dsg 3 were determined by ELISA in 35 patients with oral lichen planus and 35 healthy controls. Indirect immunofluorescence analysis was also performed. Data analysis was performed using descriptive and inferential statistics and SPSS.15. Results: Concentrations of circulating autoantibodies to Dsg 1 detected in the sera of patients with oral lichen planus were present in only low titer in sera of oral lichen planus patient but autoantibodies to Dsg 3 were significantly increased in comparison with those in healthy controls.