Comparison of salivary IgA in children in two regions, the North West of Iran with varying degrees of air pollution 1393

Abstract

Urbanized societies with transformation of the social structure, have increased energy consumption which causes numerous environmental problems. air pollution in urbanized reagions is a serious and permanent threat to the health of society and the environment. Epidemiological studies have shown a consistent relationship between air pollution and a lot of diseases. Materials and Method: 88 children (8 to 10 years old) enrolled in this cross-sectional study. 44 of them where from Tabriz and 44 of them where from Kaleibar; both in north -west Iran. Both group of study had the same socioeconomic status. Tabriz is a air polluted industrial city but Kaleibar is a rural small city with almost no air pollution. After selection of the cases, the saliva sample collected and transported to the laboratory. ELISA method was performed to detect Ig A level in the saliva. The difference between Ig A levels of two groups were analysed by independent t-test or equivalent nonparametric Mann-Whitney test and the software Spss 21. In this study, P value less than 0.05 was considered statistically significant. Results: The results of this study, show significant differences in the levels of salivary Ig A in children who live in two different regions. As salivary Ig A levels in children living Kaleibar (area with less air pollution)was higher than children who live in Tabriz (area with high air pollution). (P value = 0.001( Conculosion: the results of this study clearly indicate that the amount of salivary Ig A is reduced in air polluted regions which causes health problems in children.