Comparison of clinical effect of autogenous bone graft with and without plasma rich in growth factors in the regeneration of degree II furcation involvement of mandibular molars

Abstract

Plasma rich growth factors (PRGF). Containing autologous growth factors, has been shown to promote soft tissue healing. The purpose of this randomized controlled, clinical investigation, was to evaluate the difference in clinical parameters of the treatment of the treatment of grade II mandibular molar function involvement, utilizing autogenous bone graft with and without plasma rich in growth factors (PRGF). Methods: 30 mandibular molars with grade II forcation involvement in 30 patients were treated. Test site were received bone graft plus PRGF, while control sites were treated with bone graft only. Clinical parameters included: Clinical probing depth (CPD),Vertical clinical attachment level (V-CAL), Horizontal clinical attachment level (h-CAL), Location of the gingival margin. (LGM), Surgical exposed Horizontal probing depth of bony defect (E-HPD), Vertical depth of bone crest (V-DBC), Vetrical depth of the base of bony defect (V-DBD), Length of the intrabony defect (LID). After 6 monthes patients gone under re-entry surgery all data were analyzed by SPSS 14, Kolmogrov, U-mann-whitney and Paried T. test. Results : After 6 monthes, both of treatment led to significant improvement in v-CAL and h-CAL and significant decrease in CPD, E-HPD, V-DBD and LID. There was no significant difference in LGM and V-DBC in two treatment groups compared to baseline. Also, there was no significant difference in any of the parameters between the study groups. Conclusion : Based on the results of this study, the application of PRGF in treatment of furcation involvement with bone graft, provides no clinically enhancements on the therapeutic outcomes, but more researches is necessary.