Comparison level of the IL-6, TGFB, IL-1 Effects on oral and dental disease causes by Streptococcus Mutants and healthy tissue of the third molar without caries

Abstract

Streptococcus mutans is a species of streptococcus as a normal flora of mouth and upper respiratory system in human.Goal: The goal of this research is to investigate the pro-inflammatory cytokines in the mouth diseases with Streptococcus mutans.Methods and materials: at first from 70 patients referred to private office after preparing culture specific for Streptococcus mutans the diseases occurred by this infectious agent were removed then by extraction of inflammatory cells like macrophage from infectious inflammatory tissues IL-6, TGFB, IL-1a expression was measured and also by measuring expression of the inherent immune receptors the route of mechanism of the effect of these cytokines on Th17 was examined to find that how the mechanism of effect of these cytokines increases inflammation in these diseases.Findings: according to the data, 40 patients (1.57%) were infected with Streptococcus mutans and 30 patients (9.42%) were infected with other agents. IL-6 level was high in 30 patients (6.08%) and TGFB, IL-1a expression level was high in 40 patients with Streptococcus mutans. In the patients, increase of TLR2, TLR4 expression level was high in 30 patients (6.08%).Conclusions: Increase in inflammatory cytokines expression in the infectious mouth and teeth diseases can be result of inherent immune system stimulation with TLR or NODLR receptors.