Comparison effect of 3Mixtatin + MTA and MTA in repair of perforation or resorption region at root of primary molars of 3 to 6 years old children

Abstract

The aim of the present study is to investigate effect of the combination of 3mix antibiotics as an antibacterial agent and simvastatin as an anti-inflammatory and bioinductive agent on repair of perforation or resorption region at root of primary molars (3Mixtatin, an acronym of 3Mix and Simvastatin(. Materials and Methods. Eighty primary molars that candidate to extraction because of interradicular and/or periapical root resorption/perforation due to infective or inflammatory conditions were selected through radiographic examination and divided in two groups including 3mixtatin + MTA (Group A) and MTA (Group B) in the present randomized clinical trial. In group A, mixture of 3mixtatin + MTA powder and normal saline was delivered to perforation site or resorption region using small endodontic amalgam carrier and plugger instrument. In similar procures, in group B, mixture of MTA and normal saline was used. Teeth were restored with a stainless steel crown, amalgam or composite restoration.The teeth have been followed up 1 and 4 months after treatment. In each follow up appointment, radiographies were taken and evaluated with two examiners. Results.At the end of 4months, group A had no clinical symptoms, and the progress of resorption was stopped and of radiolucency was repaired in all cases. None of teeth with application of MTA + 3Mixtatin was extracted. In group B, eighteen teeth revealed clinical symptoms. As group A, the progress of resorption and interradicular radiolucency were stopped but none of them was repaired. Nine cases in group B were extracted due to pain. Although we have considered other clinical symptoms, as failure in this group and treatment of eighteen cases were unsuccessful. Conclusion. The finding of this study suggested that 3Mixtatin + MTA is excellent combination for preserving hopeless primary teeth