Clinical and genetic association between Interleukin -17 a gene polymorphisms and risk of oral lichen planus (OLP) in Azeri population

Abstract

Lichen planus (LP) is a chronic disease that affects the skin and oral mucosa. Although the exact cause of LP is not known, its major etiologic factors are genetic tendency and immunological factors. The objective of this study was to assess the association of interleukin17A (IL-17A) with Oral lichen pLanus (OLP). Materal and Methods: 22 adult patients with OLP and 40 healthy controlswere genotyped by polymerase chain reaction and DNA direct sequence technology for the polymorphism of the IL-17A gene. Results: The genotype frequencies of R29Q (1776G>GA), c.672 (3566G>GA)and Y85N (31292T>TA) in the IL-17A gene polymorphism were 9%,13.6% and 6.8% in the OLP group and 0%, 40% and 0% in the controls, respectively. Conclusion: Although the proportion of detected polymorphisms were not different between individuals, a higher prevalence of 3566G>GA c.672 homozygote polymorphism (4.5%) was observed in the OLP patients. Subsequent stratified analysis by gender showed that there was no statistically significant difference in the genotype and allele frequencies between the male patients and the control group. In conclusion, our results show no statically significant difference in the IL-17A genotype SNP(Single-nucleotide polymorphism)s distribution among the two groups. Therefore, further studies on a larger population and novel genetic variants are neededto better understand the pathobiology of OLP.