A comparative clinical study of subepithelial connective tissue graft with and without the use of Plasma rich in growth factors in the treatment of Miller I,II gingival recessions

Abstract

Plasma rich in growth factors (PRGF), containing autologous growth factors, has been shown to promote soft tissue healing. The purpose of this randomized controlled, clinical investigation was to evaluate the differences in clinical parameters of root coverage procedures utilizing subepithelial connective tissue graft (SCTG) with and without plasma rich in growth factors (PRGF). Methods: Twenty contralateral sites in 6 patients with >3 mm of Miller class I and II buccal marginal tissue recession were treated. Test sites received (SCTG) plus PRGF while control sites were treated with SCTG only, with each patients serving as his own control. Clinical parameters included recession depth (RD), percentage of root coverage (RC), recession width (RW), attached gingival (AG), width of keratinized tissue (WKT), clinical attachment level (CAL), probing depth (PD). Patients were followed for 3 months post-surgery. All data were analyzed by two sample t-test and SPSS. Results: All of patients completed the study. After 3 months, the mean root coverage was 72/7212 % in the SCTG group and 75/0825/12 % in the SCTG +PRGF. Both of treatments led to significant improvement in the recession depth (RD), recession width (RW), clinical attachment level (CAL), keratinized tissue (WKT)I?attached gingival (AG) and root coverage (p<0.001). There was no significant difference in the depth of pocket (PD) in two treatment groups compared to baseline. Also, there was no significant difference in any of the parameters between the study groups. Conclusion: Based on the results of this study, the application of PRGF in root SCTG coverage procedure provides no clinically enhancements on the final therapeutic outcomes, but more research is necessary.