Frequency of neurological and psychological disorders in patients with bullous pemphigoid disease

Abstract

Bullous pemphigoid disease is the most common autoimmune bullous skin disease, typically presents with tense bullae on an erythematous, urticarial base. it mainly affects individuals over the age of 65 years. Clinically observed blistering correlates histologically to subepidermal cleavage, caused by autoantibodies directed against hemidesmosomal proteins BP180 and BP230 at the dermo epidermal junction. According to studies, these proteins are also expressed in low amounts in the central and peripheral nervous system and are involved in the development of some neurological and psychological diseases. Therefor, the likelihood of bullous pemphigoid being associated with neurological and psychological diseases is high. Methods & Materials: Our study is a cross-sectional analytical type and examines all the people hospitalized due to bullous pemphigoid disease from September 2012 to September 2022 at Sina Hospital in Tabriz.The sample size was estimated to be 100 people. Finding: out of 42 men in this study, 11 had a stroke, 4 had Alzheimer disease, 3 had dementia, 2 had MS and 2 had depression. Out of 58 women in this study, 15 had a stroke, 6 had Alzheimer, 7 had dementia, 3 had MS, 13 had depression and 1 had Parkinson disease and 13 people did not have any of the diseases. In other words, out of 100 people in the statistical population, 26 had stroke, 10 had Alzheimer, 10 had dementia, 5 had MS, 15 had depression and 1 had Parkinson, while 33 people did not have any of the above diseases and there were no seizure in either group of men or women.