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dc.contributor.advisorShanehbandi, Dariush
dc.contributor.authorImani, Reza
dc.date.accessioned2025-07-15T09:23:47Z
dc.date.available2025-07-15T09:23:47Z
dc.date.issued2024en_US
dc.identifier.urihttps://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/72548
dc.description.abstractIntroduction Recently, various studies have focused on the therapeutic potential of shikonin in various human malignancies, including osteosarcoma. However, the underlying mechanisms in shikonin-mediated anticancer effects are still not fully understood. Therefore, the present study investigated the effect of Linarin on Doxorubicin-induced apoptosis in SAOS-2 cells. Methods SAOS-2 cells were treated with Doxorubicin, Linarin and a combination of both, and cell viability was evaluated by MTT method. The mRNA expression of Bax, Bcl-2, and Caspase-9 was evaluated using qRT-PCR. Apoptosis was also investigated by flow cytometry. Results Doxorubicin resulted in significant inhibition of cell proliferation in a dose-dependent manner. The combination of doxorubicin and linarin resulted in significant inhibition of proliferation compared to single treatments (P<0.05). Linarin also induced apoptosis through modulating the expression of Bax, Bcl-2 and caspase-9. Furthermore, shikonin increased cisplatin-induced apoptosis in SAOS-2 cells.en_US
dc.language.isofaen_US
dc.publisherTabriz University of Medical Sciences, Faculty of Medicineen_US
dc.relation.isversionofhttps://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/72547en_US
dc.subjectosteosarcomaen_US
dc.subjectdoxorubicinen_US
dc.subjectapoptosisen_US
dc.subjectlinarinen_US
dc.titleInvestigating the effect of linarin in increasing the sensitivity of osteosarcoma cells to doxorubicinen_US
dc.typeThesisen_US
dc.contributor.supervisorYousefi, Bahman
dc.identifier.docno6012009en_US
dc.identifier.callno12009en_US
dc.description.disciplineMedicineen_US
dc.description.degreeMD Degreeen_US


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