Evaluation of the relationship between serum homocysteine and one-year mortality in patients with STEMI undergoing primary percutaneous coronary intervention

Abstract

Inflammatory processes that follow atherosclerosis can lead to the formation of thrombus due to contact erosion of the atherosclerotic plaque surface, causing myocardial infarction (MI). Homocysteine, a sulfhydryl-containing amino acid, causes vascular damage by increasing oxidative stress. will be Considering the limitations of prospective studies in this field, we decided to investigate the relationship between serum homocysteine level and one-year mortality rate in acute ST-segment elevation MI (STEMI) patients who undergo primary angioplasty. Methods: 55 STEMI patients referred to Shahid Madani Heart Training Center in Tabriz in 2022 who have undergone primary angioplasty (PCI) were included in this cohort study. After obtaining the necessary ethical approvals from the respected ethics committee in the university research, demographic data and atherosclerotic risk factors and angiographic information including the number and name of the involved vessels were recorded. Finally, the patients were monitored for complications and mortality for one year after the intervention. Data analysis was done by SPSS version 22 software. Results: 41 of the study participants were male and 14 were female. The serum level of homocysteine in these patients had no significant relationship with their TIMI and STR scores (P-value>0.05). Due to the non-occurrence of deaths in the studied statistical population, it was not possible to investigate the prognostic effect of homocysteine in this study.