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dc.contributor.advisorBaradaran, Behzad
dc.contributor.authorAlipour, Ali
dc.date.accessioned2025-05-26T05:28:58Z
dc.date.available2025-05-26T05:28:58Z
dc.date.issued2024en_US
dc.identifier.urihttps://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/72422
dc.description.abstractCarcinoembryonic antigen (CEA) is a critical tumor biomarker, especially for the early detection and monitoring of colorectal, pancreatic, and breast cancers. Conventional cancer diagnostic methods often suffer from high costs and invasiveness. In contrast, electrochemical biosensors have emerged as effective alternatives due to their high sensitivity, accuracy, and speed. This study aims to design and develop an electrochemical biosensor based on gold-palladium (Au@Pd) nanoparticles and molecularly imprinted polymers (MIPs) for the detection of CEA in plasma samples. Methods Au@Pd nanoparticles were synthesized via the co-reduction of HAuCl4 and Na2PdCl4, and the resulting nanocomposites were incorporated onto glassy carbon electrodes. Cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques were employed to evaluate the sensor's sensitivity and performance. Results The developed biosensor exhibited high precision and repeatability in detecting CEA. Tests conducted on human serum samples confirmed its specificity and ability to detect CEA with remarkable sensitivity and selectivity. The results highlight the potential of this biosensor for clinical applications.en_US
dc.language.isofaen_US
dc.publisherTabriz University of Medical Sciences, Faculty of Medicineen_US
dc.relation.isversionofhttps://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/72421en_US
dc.subjectCarcinoembryonic antigenen_US
dc.subjectelectrochemical biosensoren_US
dc.subjectgold-palladium nanoparticlesen_US
dc.subjectmolecularly imprinted polymersen_US
dc.titleDesigning a new electrochemical biosensor for the identification and determination of carcinoembryonic antigen biomarkers in plasma samples based on Au/Pd nanomaterialen_US
dc.typeThesisen_US
dc.contributor.supervisorMokhtarzadeh, Amir Ali
dc.contributor.supervisorSoleymani, Jafar
dc.identifier.docno6011967en_US
dc.identifier.callno11967en_US
dc.description.disciplineMedicineen_US
dc.description.degreeMD Degreeen_US


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