Association of dietary patterns, quality and variety of food with disease severity and inflammatory factors in people with non-alcoholic fatty liver

Abstract

1 2 Results: The results of this study showed that healthy food patterns such as MIND, DASH, and MD had no significant direct relation with serum levels of liver enzymes aminotransferase (AST) and alanine aminotransferase (ALT) and severity of NAFLD disease (p<0.05). There was an inverse significant relation between the MIND dietary pattern score with total cholesterol (TC) (B = -0.011, p = 0.012) and low-density lipoprotein (LDL) (B = -0.016, p = 0.016), also this relation was observed between HEI and TC (B=-0.002, p=0.009) and between HEI and LDL (B=-0.002, p=0.043). There was a significant direct relationship between MD and high density lipoprotein (HDL) (B=0.007, p=0.047). A significant inverse relationship between DQI score and body mass index (BMI) was observed (B=-1.235 and p=0.022). The serum levels of CRP had significant relation with NAFLD severity (p<0.05) Conclusion: In general, the results of this study showed that more adherence to healthy dietary patterns and higher diet quality, are related to better status of lipid profiles in NAFLD patients. Also, higher quality of diet is associated with better status of antropometric indices in these patients. Keywords: Dietary pattern, diet quality, food variety, non-alcoholic fatty liver, inflammation, NAFLD severity