dc.contributor.advisor | Montazersaheb, Soheila | |
dc.contributor.advisor | Eftekhari, Aziz | |
dc.contributor.author | Monirifar, Amirabbas | |
dc.date.accessioned | 2024-11-19T06:47:59Z | |
dc.date.available | 2024-11-19T06:47:59Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.uri | https://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/71688 | |
dc.description.abstract | Prostate cancer is among the most common cancers in men with an increasing incidence rate. Radiation therapy (RT) is a therapeutic strategy for the management of prostate cancer after surgery; nonetheless, it has different side effects on neighboring healthy cells/tissues. Moreover, radioresistance has been an increasing phenomenon in the recent years. Therefore, there is an urgent need for the introduction of a safe and effective radiosensitizing agent. Accordingly, the recent trend in the development of novel drugs is accompanied by a push toward natural compounds. Our study evaluated the effects of betanin combined with RT as a potential radiosensitizing agent in the PC-3 cell line.
Methods: MTT assay was utilized to determine the growth inhibitory impact of betanin. The possible synergistic effect was evaluated with CompuSyn software upon Trypan blue exclusion test. Apoptosis-related gene expression was evaluated via Real-time PCR and the protein expression of P21 was determined using western blotting.
Results: A synergistic anticancer effect with an optimal combination index of 0.61 was achieved by treating PC-3 cells with betanin and RT. The results pointed out that betanin synergistically triggered RT-mediated apoptosis and cell cycle arrest through modulating gene and protein expression in comparison with each of the monotherapies. | en_US |
dc.language.iso | fa | en_US |
dc.publisher | Tabriz University of Medical Sciences, Faculty of Medicine | en_US |
dc.relation.isversionof | https://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/71687 | en_US |
dc.subject | Betanin | en_US |
dc.subject | Prostate cancer | en_US |
dc.subject | Radiotherapy | en_US |
dc.title | Investigation of the role of Betanin in inceasing the sensitivity of prostate cancer cells to radiotherapy | en_US |
dc.type | Thesis | en_US |
dc.contributor.supervisor | Ahmadian, Elham | |
dc.contributor.supervisor | Ardalan, Mohammad reza | |
dc.identifier.docno | 6011749 | en_US |
dc.identifier.callno | 11749 | en_US |
dc.description.discipline | Medicine | en_US |
dc.description.degree | MD Degree | en_US |