Show simple item record

dc.contributor.advisorVarshochi, Mojtaba
dc.contributor.advisorHassani, Akbar
dc.contributor.authorAslani, Behzad
dc.date.accessioned2024-11-18T11:53:21Z
dc.date.available2024-11-18T11:53:21Z
dc.date.issued2024en_US
dc.identifier.urihttps://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/71686
dc.description.abstractAcinetobacter baumannii is a Gram-negative, non-fermenting bacterium that is frequently isolated from nosocomial infections. The organism is resistant to most classes of antibiotics, and limited options are available to treat infections caused by this organism. One of the treatment options to overcome the resistant strains of this organism is antibiotic trerapy using a combination of two or more different antibiotics. The purpose of this study was to investigate the effects of combinations of colistin + rifampin, cefotaxime + amikacin and imipenem + colistin in laboratory conditions against carbapenem resistant A. baumannii isolates. Methods: Clinical specimens were inoculated on specific growth medium and bacterial isolates were identified using standard microbiological methods. Antibiotic resistance pattern of studied isolates was determined by disk diffusion method and minimum inhibitory concentration was determined by microbroth dilution method. The synergistic effects of the studied compounds were determined by determining the FIC index using the CheckerBoard method. Results: In the present study, high levels of antibiotic resistance were observed. None of the studied isolates were resistant to colicitin. Antimicrobial effects of antagonism were not observed in any of the compounds. The most synergistic effects were in the combination of amikacin and cefotaxime and in 9 of 12 isolates.en_US
dc.language.isofaen_US
dc.publisherTabriz University of Medical Sciences, Faculty of Medicineen_US
dc.relation.isversionofhttps://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/71685en_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectcarbapenemsen_US
dc.subjectcolicitinen_US
dc.subjectsynergyen_US
dc.titleEvaluation of multidrug-resistant Acinetobacter baumannii isolates in terms of sensitivity to combination of antibiotics including colistin and rifampin, cefotaxime and amikacin, imipenem and colistinen_US
dc.typeThesisen_US
dc.contributor.supervisorHassani, Alka
dc.contributor.supervisorMemar, Mohammad Yousef
dc.identifier.docno6011755en_US
dc.identifier.callno11755en_US
dc.description.disciplineMedicineen_US
dc.description.degreeMD Degreeen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record