| dc.description.abstract | Although old age, menopause, obesity, diabetes, AUB, and atypical
hyperplasia are known as predictors of endometrial cancer, the risk factors that
indicate the accompanying concurrence of endometrial cancer with EIN have not
been identified. Since young women with EIN and simultaneous presence of
endometrial cancer who want to preserve fertility may suffer from the conservative
hormonal treatment, this study was conducted to compare some clinicopathological
characteristics of patients with endometrial intra-epithelial neoplasia with and
without endometrial cancer.
Materials and Methods: This cross-sectional analytical study was performed on
patients who have undergone pipelle biopsy or D&C or hysteroscopy and D&C and
have been admitted at Al-Zahra teaching hospital for abdominal hysterectomy with
the diagnosis of EIN (Endometrial Intraepithelial Neoplasia). Patients of any age or
with any symptoms were included in the study. Patients who had received hormonal
therapy for at least three months before hospitalization were excluded from the
study. Hysterectomy was performed with or without oophorectomy and, if
necessary, frozen section and surgical staging. Based on the pathological results of
hysterectomy samples, patients were divided into two groups with or without
concurrent endometrial cancer: the first group of patients with concurrent
endometrial cancer and the second group of patients without concurrent
endometrial cancer. The clinical characteristics obtained from all patients and the
pathology results obtained from hysterectomies were recorded and compared in the
prepared information form.
Results: A total of 1438 hysterectomy cases were included in the study, of which
85 cases (5.91%) were performed due to atypical hyperplasia (EIN), and finally 59
cases were diagnosed with endometrial cancer (69.4%). Furthermore, 26 control
people (30.6%) without endometrial cancer participated in this study. Among the
59 patients with cancer, histologically, most cases (94.9%) were of endometrioid
type. Almost 95% of the patients were in stage I, and more than 64% were in grade
I. Myometrium and lymph node involvement were 8.5% in both groups; cervix and
ovary involvement was only one case, and tubal involvement was not reported.
Also, the tumor did not metastasize in any of the patients at the time of the study.
Based on multiple logistic regression, after adjusting and keeping other variables
constant, Increasing age significantly increased the chance of endometrial cancer,
and increasing age increased the risk of developing cancer by 1.1 times (CI: 1.03-
1.16). Having bleeding before menopause also increased the risk of endometrial
cancer by 4.4 times, but this relationship did not reach a statistically significant
level (CI: 0.52 - 37.17). | en_US |
