| dc.description.abstract | ABSTRACT: Surgery in the oral cavity causes damage to the surrounding tissues and creates a scar that needs time to heal. Bleeding after extraction and alveolar bone loss are two common complications after tooth extraction that lead to poor recovery and rehabilitation problems. Bleeding after tooth extraction and alveolar bone loss are two common complications after tooth extraction. Post-extraction bleeding is defined as continuous bleeding for more than 8 to 12 hours after extraction, and if untreated, it can lead to a variety of soft tissue complications caused by a simple hematoma. Also, the mouth is a vascular area and uncontrollable bleeding in Surgical outcome may arise. In dental surgery, increased postoperative pain, swelling, and bleeding are associated compared to flap repositioning and secondary repair. Unhealed wounds represent a challenging clinical problem, they are an important source of Disease and infection, as well as social and economic burden, constitute a significant social and economic burden. Dressing materials are used to reduce bleeding and postoperative pain, heal wounds, and prevent infection. Studies have been conducted in an effort to design hemostatic materials with wound healing properties, but still drugs A limited number of hemostat and antibacterial materials have been designed to be suitable for use in the socket after tooth extraction. Alveolar bone loss as the second complication after tooth extraction often leads to damaging the results of prosthetic rehabilitation. To solve this problem, preserving the alveolar ridge has been introduced to reduce the erosion and facilitate the restoration of the prosthesis and aesthetics after extraction. Preservation of the alveolar ridge involves the use of bone grafting material in the extraction sockets. Existing wound dressings do not have strong hemostatic and restorative properties, which reduces their effectiveness (such as Periogen/ Teruplug/ CollaPlug/ Emdogain/ Fibrin Sealant, etc.). Therefore, the necessity of designing a new generation of powerful wound healing, osteogenic and hemostatic agents is felt, which can activate the physiological pathways of healing, including the control of bleeding (as a barrier and activator of bleeding) and, on the other hand, provide a platform for migration. and multiplication of growth factors and acceleration of matrix formation and bone tissue remodeling
Method:The present study investigates the effectiveness and biocompatibility of polysaccharide hydrogel consisting of alginate and carboxymethyl cellulose along with Laponite nanoparticles modified with eggshell fiber to control bleeding and repair alveolar bone. became In this study, 60 Wistar rats were selected and after extraction of the right mandibular tooth of the lower jaw, a 10 mg cylindrical piece from the first treatment group (ACL) (the second group) (ACLE, the third group, the positive control (Gelita-Cel®) and the fourth group (CONTROL) - ) were implanted in the oral socket and were treated for 60 days. Then, on the 14th, 30th, and 60th days after surgery, after taking blood from the heart of rats, samples were taken from the tissues of the jaw, liver, and kidney. Clinical and histopathological examinations were performed.
Results:The results of the histopathology evaluation confirmed the increase in bone formation in the treatment groups, and with hematoxylin and eosin staining, no host immune reaction or severe inflammation was found in the treatment groups. In general, all experimental groups of bone tissue showed normal structure. In the last period of treatment and after From 60 days, more mature bone trabeculae with clear thickness, along with small islands of connective tissue were observed in the alveolar cavity and tooth cavity space. It should be noted that spongy and porous bone was observed in the control groups, while in the treatment group, more and faster recovery with showed less porous bone after 60 days.
In the statistical analysis, a significant difference was observed between the negative control group and other treatment groups, P<0.05, while no significant difference was observed between treatment groups 1 and 2 and the positive control, P>0.05.
The results of evaluating the biodegradability of the synthetic material: Considering that the synthetic material was implanted in the socket, after 60 days, they almost returned to normal and the socket was completely closed, and the body did not react to the synthetic material, which indicates its biodegradability. And the compatibility of the synthetic material has been. | en_US |
