Evaluation of the effect of Dual FSH/HCG triggering on the success rate of IUI in couples diagnosed with unexplained infertility

Abstract

Although assisted reproduction technology (ART) success has been improved almost 30% of infertile couples worldwide are diagnosed with unexplained infertility. The study objective was to evaluate the pregnancy rates among primary unexplained ladies who were affiliated with FSH administration at the time of the hCG trigger in comparison with hCG trigger alone. Methods: A parallel randomized controlled trial was conducted involving 80 ladies with primary unexplained infertility at Al-Zahra Referral Academic Center. Participants were randomly allocated into two groups (40 subjects in each group). Intervention group received two ampules (75 IU) of follicle-stimulating hormone (FSH) plus two ampoules (5000 IU) of human chorionic gonadotropin (hCG) while the control group received only hCG using intrauterine insemination (IUI) after 34-36 hours triggering to improve the pregnancy rates. Results: There was no significant relation between-groups regarding demographic and clinical characteristics such as endometrial thickness, and the number of follicles before intervention (p>0.05). The clinical pregnancy proportion was 22.5% (9/40) in hCG group versus 35.0% (14/40) in the dual FSH and hCG group; (p=0.048). While chemical pregnancy rate was 30.0% (12/40) versus 37.5% (15/40). No significant associations were found for biochemical pregnancy and the number of gestational sacs (p>0.05).