Measurement of, interleukin 6 levels, liver enzyme levels and lung CT scan in Covid 19 patients and their comparison with the patient's clinical outcome

Abstract

Due to the high incidence and transmissibility of Covid 19 disease and the need to understand the mechanisms of destruction in lung tissue and the development of acute respiratory syndrome And the need to understand the mechanisms of destruction in lung tissue and the development of acute respiratory syndrome, Evaluation of serum levels of inflammatory mediators IL6 And comparing the obtained values with the severity of clinical outcome , liver function level and chest CT results in these patients can provide useful information for diagnosing the disease as well as ways to treat this disease in the country. Materials and Method: The current study of serum samples of patients with covid-19 who were hospitalized in the wards dedicated to these patients in Imam Rezai Hospital in Tabriz and samples were taken from them for therapeutic purposes during their hospitalization. The rest of the serum samples were taken from by maintaining the principle of confidentiality of the patients' characteristics and keeping the cold chain, was transferred to one of the laboratories of the province to measure the serum level of interleukin 6 as well as the level of liver enzymes and was kept frozen in this laboratory. In this retrospective study, information related to the age, sex, underlying disease and clinical outcomes of the patients regarding their recovery or non-recovery (patient death) were also extracted by referring to the patients' files and at the same time, the CT scan of these patients was obtained by the consultant radiologist and the relevant information was statistically analyzed. It should be noted that no additional intervention was performed on the patients, and the number of serum samples collected from the patients was 66 samples according to the cost of purchasing the kits. It should be noted that the kits related to interleukin 1 have also become rare and therefore were inevitably excluded from the study. Results: The level of interleukin 6 among these 66 patients was minimum 8 and maximum 220 with an average of 47.73. Comparing the values of interleukin 6 and the clinical outcomes of patients indicates the existence of a statistically significant relationship with a p-value of 0.0 between these two variables. The comparison of interleukin-6 levels and the amount of pulmonary involvement of patients indicates the existence of a statistically significant relationship between the level of pulmonary involvement of more than 50% and higher levels of interleukin-6.