Assessment of follicular fluid leptin levels and insulin resistance as outcome predictors in intracytoplasmic sperm injection

Abstract

Leukemia is related to the hematopoietic tissues of the body, and acute myeloid leukemia (AML) is a common and fatal type. Modulation in the immune system is a new and promising treatment for AML patients. Our aim was to evaluate the immune system of AML patients, and to highlight the clinical correlation between the percentage of lymphocytes and lymphocyte subpopulations of bone marrow (BM) on the response to treatment and the rates of overall survival and leukemia-free survival. Materials and methods: The number of 58 new patients with non-M3 AML referred to Shahid Ghazi Tabatabai Hospital in Tabriz, whose disease was confirmed by flow cytometry from bone marrow samples and underwent induction chemotherapy with 3+7 regimen, in full, from May 2016 to They entered the study in May 2018. Analysis of lymphocytes and BM subpopulations was performed by flow cytometry. Results: In the group that achieved complete recovery (CR), the total values of BM lymphocytes, T cells were significantly higher compared to the treatment-resistant and premature death groups, P values were P < 0.0001 and P < 0.0341, respectively. In addition, overall survival (OS) and leukemia-free survival (LFS) were significantly longer in patients with high BM and T cell lymphocytes.