Examination of fecal calprotectin level in patients with Entamoeba histolytica from 2020 to 2022

Abstract

Studies have shown that Calprotectin can differentiate inflammatory bowel disease from non-inflammatory bowel diseases such as irritable bowel syndrome. Also, the correlation between the amount of fecal Calprotectin with the severity of mucosal inflammation and the endoscopic index of the severity of Crohn's disease has been shown. While the endoscopic index of the severity of Crohn's disease is a tedious and time-consuming method. It is very desirable to evaluate patients and grade their risk using a cheap and non-invasive test. An ideal marker should be sensitive. Calprotectin test is a non-invasive test used to diagnose patients who have diarrhea and are suspected of IBD; The purpose of this study is whether the fecal calprotectin test is positive in gastroenteritis caused by Entamba histolytica (ambiasis) or not? Materials and Methods: This research was a descriptive-analytical cross-sectional study. The target population in this study was the patients referred to the infectious and gastroenterology clinics of Tabriz University of Medical Sciences in the period of 2019-2019, who were positive for E. H. in the stool test, and 50 patients were included in the study with an accessible or easy sampling method. were finalized. Blood samples from all patients were checked to check blood cells and (erythrocyte sedimentation rate). Stool samples were stored in plastic containers at -20°C for 6 hours until analysis. FCP was measured by ELISA method with a laboratory kit in Jihad University Laboratory and accredited laboratories in Tabriz city. FCP values are expressed in milligrams per kilogram of wet feces, and its normal value was considered to be >50 milligrams per kilogram of feces. Results: Results: among all the participants in the study, 19 of them had levels higher than 50 mg per kilogram of feces; Among these, it was found that the number of men with results higher than 50 mg per kilogram of feces was significantly higher than the number of women with results higher than mg per kilogram of feces (P=0.035). The results indicated that the duration of the disease was more than 7 days among people with positive results of calprotectin significantly more than those with negative results of calprotectin levels (P=0.018). Calprotectin levels in patients with severe disease were significantly higher than calprotectin levels in patients with mild symptoms (P=0.009).