Evaluation of Fingolimod effects on Wistar rats injured by renal ischemia-reperfusion

Abstract

Many studies have shown that restoring blood flow to ischemic tissue causes more damage to that tissue, called ischemia-reperfusion (I/R) damage. The kidney is one of the organs that is exposed to I/R damage. I/R damage increases adhesion molecules and the production of inflammatory mediators that lead to the uptake of leukocytes. Fingolimod is a new generation safety regulator that may be effective in reducing I/R damage. In this study, we investigated the effect of fingolimod consumption on I/R damage. Method: Twenty-four adult male Wistar rats were divided into 4 different groups based on fingolimod consumption and I/R induction and the level of antioxidant factors in each of these mice was evaluated. Finally, the levels of these factors were compared between different groups of mice. P-Value < 0.05 was considered significant. Results; The levels of SOD, GPx, TAC, GSH are reduced by I/R in kidney tissue, which increases the risk of kidney damage. It was also shown that the amount of these factors in the kidney tissue is compensated by the use of fingolimod and approaches the normal level.