Comparison of tranexamic acid and dexmedetomidine in controlling bleeding during femoral cone implant surgery with a history of heart disease: a randomized clinical trial

Abstract

Considering that trauma patients who have a history of heart diseases are exposed to increased bleeding and instability of the hemodynamic state during the insertion of femoral braces, preventive measures against bleeding should be considered. Therefore, the purpose of this study is to compare two drugs, Tranexamic acid and dexmedetomidine, in the control of bleeding during femoral contor implantation surgery in trauma patients with a history of heart disease. Methods: This study is a clinical trial that was conducted in 1400 with the participation of patients who are candidates for femoral contor implantation. 120 patients with heart diseases entered this randomized clinical trial study and were blinded on both sides; Patients were divided into two groups. The patients in the dexmedetomidine group received an infusion of half a microgram per kilogram per hour. This medicine was diluted in a 50cc syringe and infused. Tranexamic acid group patients also received 20 mg/kg of the drug before surgical incision; Bleeding rate, bleeding volume, number of blood bags received and hemoglobin changes were compared between two groups. Results: The average intraoperative and postoperative bleeding is insignificantly higher in the dexmedetomidine group than in the tranexamic group; There was no significant difference in the amount of transfusion during and after the operation in the two studied groups. The average amount of platelets before and after the operation in the dexmedetomidine group is not different from the amount of platelets in the tranexamic group. The average post-operative hemoglobin is insignificantly higher in the tranexamic group than in the dexmedetomidine group. The average HCT level on the morning after the operation in the first 24 hours after the operation (between the first 16-24 hours after the operation) is non-significantly higher in the tranexamic group than in the dexmedetomidine group. The average postoperative fibrinogen is non-significantly higher in the tranexamic group than in the dexmedetomidine group. The satisfaction of the surgeon is insignificantly higher in the Tranexamic group than in the dexmedetomidine group.