The effect of using gelatin sponges impregnated with Teriparatide on the incidence of dry socket and pain intensity after tooth extraction

Abstract

Introduction: Alveolar osteitis (*AO) or dry socket) is a difficult and common complication after tooth extraction, especially mandibular molars, whose prevalence is reported to be between 20 and 35%. The aim of this study is to investigate the effectiveness of Teriparatide, a hormone of parathyroid origin, compared to placebo (normal saline) in reducing the incidence of (AO) after extraction of mandibular molars. Materials and methods: This study is a randomized and double-blind clinical trial with code IRCT20230627058604N1 was conducted on 82 mandibular molar teeth in 41 patients aged 18 to 50 who were candidates for bilateral extraction of mandibular molars. after the extraction of the tooth, on one side of the patient’s mouth, a collagen sponge soaked in Teriparatide solution for 5 minutes was placed in the socket and a (figure 8) suture was made. On the other side, a collagen sponge without medication soaked in normal saline was placed in the area and the suture was performed as on the other side. Pain and the clot condition were assessed individually on days 1, 3, 7 after tooth extraction by a dentist without knowing the side of the intervention. (*VAS) chart was used to check the pain intensity. The results were statistically analyzed by chi2 and independent t-test with SPSS software.

Results: In this study, 82 teeth of 41 patients were examined as split mouth. 51.2% of patients were male and 48.8% were female. - The mean (standard deviation) of pain according to the VAS chart in the intervention group with teriparatide is (1.46) and in the placebo group (1.84). - The incidence of dry mouth in the teriparatide intervention group is 4.88% and in the placebo group it is 9.76%. Conclusion: - Teriparatide has no significant effect in reducing the intensity of pain after tooth extraction. - Teriparatide is effective in reducing dry socket after tooth extraction.