The effect of nifedipine on the success of embryo transfer cycles in patients with recurrent implantation failure

Abstract

In- vitro fertilization (IVF) is one of the approved treatment options for infertility. Despite many progresses in this field, its success rate is about 20 -25 Utilization of drugs which suppress or decrease uterine smooth muscle contraction before embryo transfer, theoretically can improve fertility by increasing rate. This study was designed to evaluate nifedipine administration on embryo transfer success. Material and methods: In this interventional clinical trial, 60 infertile women due to primary and secondary causes were studied. All people have already had a failed IVF cycle. Subjects received a 10 mg dose of nifedipine 2 hours before embryo transfer. The initial report was defined as clinical pregnancy and outcomes as live birth, ectopic pregnancy, multiple births and abortion. Results: Clinical pregnancy occurred in 15 patients who took nifedipine. 5 cases of twin pregnancy and 1 case of multiple pregnancy and 3 cases were observed. The side effect was not so much among the people of the drug and the highest pressure was in 5 people. Fetal age was positive in 60% of pregnancy test results. Among 66.7% of them, the result of positive pregnancy test was 2 embryos.