Investigating the relationship between MYOM2 and IFI27 expression with late-onset Alzheimer’s disease

Abstract

Alzheimer's disease (AD) is the most common form of dementia in elderly people, and its prevalence is increasing worldwide. The myomsin-2 (MYOM2) gene encodes a protein that is one of the main components of the M-band of the sarcomere. Alpha interferon-inducible protein gene (IFI27) is a novel modulator of the innate immune system involved in the interferon signaling pathway. These genes may play a role in AD pathogenesis through pro-inflammatory response and neuronal cell death. In this research, an attempt was made to investigate MYOM2 and IFI27 genes in AD disease in peripheral blood related to the possible mechanism of AD pathogenesis. Method: By reviewing the literature, the mechanisms and pathways involved in the pathogenesis of Alzheimer's disease were identified and studied. MYOM2 and IFI27 genes were measured in terms of gene expression and expression correlation graphs were drawn in the blood of patients compared to the blood of healthy controls. Quantitative polymerase chain reaction technique was also used to investigate the expression of these regulatory factors in the peripheral blood of 50 Alzheimer's patients and 50 controls. Results: In this study, by examining the expression levels of MYOM2 and IFI27 genes in the peripheral blood of people with Alzheimer's compared to healthy people, it was concluded that the expression levels of these two genes do not show significant changes in the blood. Interestingly, these two genes were significantly correlated in terms of expression.