dc.description.abstract | Anal fissures are one of the common anorectal disorders. Based on re-ports, one in five people will develop anal fissures in their lifetime. An anal fissure is a superficial and longitudinal tear in the endoderm, dis-tal to the dentate line, that continues down to the edge of the anus. Generally, there are two kinds of treatment for anal fissure: 1. Medical treatments and, 2. Surgical treatments. The goal of the current study is to find an effective medical treatment for this disorder. In line with this goal, effects of Ansil gel (Silver nanoparticles) on anal fissure patients were studied.
Material and Methods: In a double-blind randomized clinical trial, 50 patients with anal fissures were divided into two intervention and con-trol groups. Patients in the intervention group were treated with Ansil topical gel twice a day for two weeks. The control group was treated with placebo gel twice a day for two weeks. The purpose of this study is to investigate the restorative effect of the combination of silver nanopar-ticles with tannic acid on the treatment of acute anal fissure wounds and also to investigate the possible side effects of the drug through ex-amination and questionnaire.
Results: In this study, 25 people were investigated in the intervention group and 50 people in the control group. After conducting the study and examining the questionnaires of the patients of the two intervention and control groups, the results show a significant difference in the symptoms of anal itching, anal bleeding, anal pain at rest and during defecation, feeling the pulse after defecation, feeling the mass around the anus, bleeding during examination and pain during examination between the patients of the intervention group and the control group before and after taking the drug. (p-value=0.000) However, there was no significant difference between the control and intervention groups regarding the presence of anal fissures according to the examination after treatment with the drug. (p-value = 0.15) | en_US |