Cerebral venous thrombosis (CVT) following COVID-19 vaccination: A systematic review

Abstract

Considering that previous studies have shown a significant relationship between the occurrence of cerebral vein thrombosis (CVT) and vaccination of Covid-19, as well as numerous cases of CVT following the receipt of various vaccines of Covid-19 and the importance of vaccination to fight this disease. Taken together with other published systematic reviews and meta-analyses, this umbrella review of systematic reviews provides a comprehensive overview of the evidence for the association of CVT vaccination and COVID-19. Methods: We searched related databases to access issue-related systematic reviews both with meta-analyses and without it that studied the connotation between COVID-19 vaccination and CVT in any language on March 1, 2022. Two reviewers independently extracted the data using the JBI Form for Data Extraction in Systematic Reviews and Research Syntheses. Results: The primary search resulted in 886 titles, and finally, 48 full texts were selected, and of these, 12 qualitative systematic reviews or quantitative meta-analyses were eligible for the umbrella review. No study was excluded based on using the JBI checklist for critical appraisal. The results revealed that cerebral venous sinus thrombosis (CVST) from the COVID-19 vaccine could occur in any age group, in both sexes, and with all types of vaccine. However, young females were the predominantly affected cases. Although more common in adenovirus vaccine types, vaccines consisting of mRNA are not free from side effects. Headache was the most typical clinical symptom. Thrombocytopenia, PF4 IgG Assay, and d-Dimer evaluation were positive in many reported studies.