Comparison of Infusion of Dexmedetomedine and Magnesium Sulfate on the Stability of Hemodynamic Status During Elective Orthopedic Surgery in Obese People: A Randomized Clinical Trial

Abstract

Since obese people are subject to hemodynamic instability during anesthesia and preventive measures for these people should be considered by the anesthesiologist, we decided to investigate the effects of dexmedetomidine and magnesium sulfate infusion on hemodynamic stability during surgery To examine and compare elective orthopedics in obese people. Methods: This study is a clinical trial that was conducted in the orthopedic operating room of Imam Reza Hospital during the year 2021. After a pilot study, the sample size was considered equal to 80 people and the samples were randomly divided into two groups. A group of patients received magnesium sulfate at the rate of 50 mg per hour half an hour before the start of anesthesia. Patients in the other group received dexmedetomidine infusion half an hour before surgery at the rate of half a microgram per kilogram per hour. This medicine was diluted in a 50 cc syringe and infused. The hemodynamic status of the patients between the two groups was recorded and finally compared with each other. Results: Blood pressure in magnesium group patients was non-significantly higher than in dexmedetomidine group patients. Intragroup comparison of blood pressure indicated that blood pressure stability was higher in dexmedetomidine patients group (P=0.559) than magnesium group patients (P=0.403). The heart rate in the patients of the dexmedetomidine group was insignificantly lower than the patients of the magnesium group. The intra-group comparison of heart rate indicated that the stability of heart rate was higher in the group of patients receiving dexmedetomidine (P=0.613) than in patients receiving magnesium (P=0.445); Also, the stability of arterial oxygen saturation in patients receiving dexmedetomidine (P=0.529) was higher than in patients receiving magnesium (P=0.386). The average recovery time in the magnesium group was non-significantly lower than the group of patients receiving dexmedetomidine (P=0.360).