Effect of spongy gelatin membrane containing nanocurcumin and nanohydroxyapatite on bone regeneration and improvement the soft tissue quality in extracted socket: A Clinical Trial By

Abstract

Introduction: Bone defects are among the serious problems in oral and dental health in different societies. In this research work, the effect of spongy gelatin membrane containing nanocurcumin and nanohydroxyapatite on bone regeneration and improving the quality of soft tissue in the extracted tooth area was investigated in the form of a clinical trial study. . Materials and Methods: The mentioned membranes were used in 20 split mouth patients who were early implant candidates to check the quality of ossification. On the intervention side, a sponge membrane containing nanocurcumin and nanohydroxyapatite was placed in tooth socket and sutured and on the control side without any intervention. Mentioned socket was a four-wall type of single-rooted or double-rooted teeth. After placing the membranes, the tooth socket was sutured using a 5-0 suture. After 2 months, the second maxillofacial surgeon, who was not aware of the type of intervention, took a sample and placed the implant. During implant placement, the bone required for histological examination was removed with the help of a fine osteotome or trephine bur. The thickness of the gum in the part where the bone was removed with a fine osteotome or trephine bur was measured with a periodontal probe and compared with the thickness of the gum with the control group. After H&E staining, each section was examined by Optical microscope. Using image analysis software, the amount of newly formed bone was reported as a percentage of new bone to the entire surface of the examined section. Independent T test was used for statistical analysis of data. The data was analyzed by SPSS software version 24, and the significance level was considered to be ≥0.05p. Results: In histological studies, spongy gelatin membrane containing nano curcumin and nano hydroxyapatite had a significant effect on improving the quality of gum tissue. In examining the amount of bone regeneration, there was no significant difference between the control group and the intervention group. Conclusion: In this study, the follow-up period in this study was short and was carried out for two months. Also, the number of participants could be more than the number of present participants in this study.