Association of CD38 expression in flow cytometry of patients with newly diagnosed acute myeloid leukemia and their overall survival in East Azerbaijan province

Abstract

Acute myeloid leukemia (AML) is a rare but aggressive type of cancer with different survival rates around the world. While factors such as age, cytogenetic, and molecular abnormalities play an important role that impacts the prognosis of AML patients, we investigated the correlation between CD38 and other hematologic markers and the survival of AML patients. Methods: We analyzed CD38 expression on AML blasts by flow-cytometry and its association with overall survival (OS) and one-year survival in 72 newly diagnosed AML patients in Hematology-Oncology Research Center, Iran, Tabriz.

Results: Seventy two newly diagnosed non M3-AML patients were followed in this study. The results showed there was a significant relationship between overall survival and one year survival CD38 levels. Besides, Increasing of CD38 level by 1% increased the hazard of mortality by 1 percent (HR=0.99; 95% CI: 0.98 to 1.01).