Evaluation of macular microvascular structure in patients with history of Retinopathy of Prematurity (ROP) that cured with Bevacizumab in comparison with premature patients without ROP and with ROP that regressed

Abstract

The microvascular features of parafovea in eye diseases are important and vital for better diagnosis and treatment of patients, so the purpose of this study is to investigate the microvascular characteristics of the macula in children with a history of retinopathy of prematurity treated with Avastin (bevacizumab) and compare it with premature children without retinopathy and has retinopathy with spontaneous improvement. Introduction: The microvascular characteristics of parafovea in eye diseases are important and vital for the better diagnosis and treatment of patients, but so far no study has been done about microvascular pattern in retinopathy of prematurity and the effect of its stages. The aim of this study was to Evaluation of macular microvascular structure in patients with history of Retinopathy of Prematurity (ROP) that cured with Bevacizumab in comparison with premature patients without ROP and with ROP that regressed. Methods: In a cross-sectional study on 150 patients, the participants in the study first underwent a complete ophthalmological examination and then underwent OCTA. Microvascular structure in the parafovea, superficial and deep vascular density in the fovea and Para fovea, avascular zone of the fovea and microvascular abnormalities were evaluated, and the normal and abnormal vascular pattern and density were expressed as a percentage. Became. After collecting the data, SPSS-21 was used to analyze the data. Results: In this study, a total of 150 patients were examined in three groups. 50 premature patients without ROP, 50 children with ROP that regressed and 50 children with a history of ROP that cured with Bevacizumab, were compared. The density of the superficial vascular structure of the parafovea in patients with a history of ROP cured with Bevacizumab (49.95±5.15) was higher than the density of the other two groups. The density of deep vascular structure of parafovea in patients without ROP was lower than other groups (26.81±31.15). Micro aneurysm and vascular telangiectatic changes were observed in 76% of patients with a history of ROP cured with Bevacizumab. The density of the avascular zone of the fovea in patients without ROP was higher than the other groups (0.23±0.12).