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dc.contributor.advisorHassannia, Hadi
dc.contributor.advisorGhalamfarsa, Ghasem
dc.contributor.authorAlizadeh, Mohammad
dc.date.accessioned2023-08-06T06:51:53Z
dc.date.available2023-08-06T06:51:53Z
dc.date.issued2022en_US
dc.identifier.urihttps://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/69129
dc.description.abstractOne of the effective ways to treat cancer can be to target immune-suppressing mechanisms in the tumor microenvironment. One of these therapeutic targets is the CD73 molecule, an actoenzyme that produces adenosine, a highly inhibitory factor in the host. PI3K / Akt is an important pathway in cell growth that also plays an important role in tumorigenesis. Studies have shown that CD73 activates the PI3K / Akt signaling pathway in cells and promotes further tumor growth. Therefore, in this study, our goal was to block this reinforcing loop. Materials and Methods: In this study, hyaluronate-coated trimethyl chitosan nanoparticles were used to transfer CD73 and Akt specific siRNAs to three cancer cell lines including 4T1, CT26 and B16-F10. Results:The synthesized nanoparticles with appropriate physicochemical properties were able to significantly suppress the expression of CD73 and Akt factors in all three cell lines. Also, combination therapy was able to significantly inhibit the expression of genes involved in the growth and spread of cancer. This treatment strategy also had a high ability to suppress the migratory and metastatic features of cancer cells.en_US
dc.language.isofaen_US
dc.publisherTabriz University of Medical Sciences, Faculty of Medicineen_US
dc.relation.isversionofhttps://dspace.tbzmed.ac.ir:443/xmlui/handle/123456789/69128en_US
dc.subjectCanceren_US
dc.subjectTrimethyl chitosanen_US
dc.subjectNanoparticlesen_US
dc.subjectCD73en_US
dc.subjectAkten_US
dc.titleStudy of anti-cancer effects of inhibition of CD73 and Akt molecules by siRNA-loaded Nanoparticlesen_US
dc.typeThesisen_US
dc.contributor.supervisorJadidi-Niaragh, . Farhad
dc.contributor.supervisorDr. Dolati, Sanam
dc.identifier.docno6010960en_US
dc.identifier.callno10960en_US
dc.description.disciplineMedicineen_US
dc.description.degreeMD Deegreen_US


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