Evaluation the efficacy of some complexation methods in preparation of Piroxicam/Hydroxypropyl beta cyclodextrin complexes

Abstract

Introduction: Piroxicam is an anti-inflammatory drug from the category of painkillers and non-steroidal anti-inflammatories that is widely used in the pharmaceutical market of Iran. One of the main problems of this category of drugs is their gastrointestinal side effects, which are applied directly and indirectly (systemically).Objective: In this study, an attempt was made to reduce the direct side effects of this medicinal substance on the stomach wall by creating a drug complex with hydroxypropyl beta-cyclodextrin. For this purpose, various methods of drug-hydroxypropyl beta-cyclodextrin complexation have been used, which include the kneading method.Methodology: Drug and piroxicam were mixed with different ratios and processed by the mentioned methods. The obtained products were studied with DSC and FTIR spectra to ensure the possibility of complex formation as a result of the process. In the next step, the release of the drug from the products obtained in the reconstituted stomach (SGF) and intestinal (SIF) environments was studied in order to simulate the behavior of the drug in the body.Results: The results of DSC and FTIR spectra did not confirm the formation of a complex with all the methods used, except the complexation method with tripolyphosphate, but the results of the dissolution test in SGF medium showed a very obvious difference in the dissolution pattern of the drug.Discussion and conclusion: Although the formation of the complex was not confirmed by most of the methods used, but increasing the dissolution rate of the drug in the SGF environment can reduce the contact of the drug particles with the stomach wall and direct stimulation of the stomach, which is the main goal of this study.