Value of serum albumine in vasopressordose and lactate clearance in critically ill septic patients inICU

Abstract

If albumin can reduce the need for vasopressor and fluid intake, it can be expected that serum albumin at the time of hospitalization can be associated with significant ICU outcomes in the first 24 hours of hospitalization, so this marker can be a reliable and reliable predictor of Patients who have a high mortality rate and need more care. Therefore, in this study, we aimed to investigate the relationship between patients' initial serum Alb levels with the diagnosis of septic shock and their vasopressor dose and lactate clearance. Materials and Methods: In this cross-sectional descriptive study, 99 patients with sepsis diagnosed admitted to the intensive care unit of Shohada Hospital (affiliated to Tabriz University of Medical Sciences) in the period of 2017-2018 were evaluated; for all patients after admission to the ward Intensive care Serum albumin and lactan levels were measured and its relationship with the cumulative dose of norepinephrine in the first 24 hours of ICU was determined. Results: The median of serum albumin and lactate clearance in deceased patients was lower than in surviving patients (P <0.0001), with increasing serum albumin, clearance also increased (r=0.576 and P <0.0001) and with the duration of mechanical ventilation, vasopressor-dependent days, cumulative epinephrine cycle and mortality decrease (P<0.0001). Mortality rate in patients diagnosed with septic shock is calculated based on serum albumin level for albumin less than 2.7, 100%, and for albumin 2.7 to 2.9 equal to 8.3% (8333 per 100,000 people) The mortality rate of patients with more than or equal to 3 albumin was zero percent.