The effect of systemic injection of tranexamic acid on reducing bleeding and the need for transfusion in acetabular fracture surgeries (Transverse, T Type and associated fracture)

Abstract

Acetabular fracture surgery is associated with complications such as bleeding during and after surgery.This factor can lead to increased morbidity and mortality of patients. Blood loss and complication of correction through transfusion make a concern for the surgeon. Tranexamic acid reduces bleeding by reducing local fibrinolysis. The aim of this study was to evaluate the efficacy of tranexamic acid in acetabular fractures.

Materials & Methods: A total of 51 patients participating in the study were randomly divided into two groups: TXA and control. Preoperative and postoperative hemoglobin, intraoperative and postoperative bleeding volume, as well as DVT symptoms were recorded in both groups and analyzed by SPSS software.

Results: Bleeding volume during surgery was 386.53± 76.88 in the TXA group and 854.00± 369.94 in the control group, which was a significant difference (p <0.001). 21 patients underwent packcell infusion, of which 19 were in the control group and 2 were in the tranexamic acid group (p <0.001). The mean duration of surgery was 125.38 ± 14.41 in TXA group and 156.40± 16.74 in control group (p <0.001). Postoperative bleeding volume was reported as 105.76± 51.62 in TXA group and 230.00± 47.87 in control group (p <0.001). Tranexamic acid did not increase the incidence of DVT