Effect of intravenous administration of c-kit+ cells on oxidative stress and histological changes in the lung tissue of type 2 diabetic male rats

Abstract

Considering the importance of lung damage in diabetic patients, in this study, the effect of intravenous administration of c-kit+ cells on oxidative stress index (MDA), antioxidant enzymes (SOD and GPX) and histological changes in lung tissue of Type 2 diabetic male rats were investigated. Methods: Forty eight male wistar rats were divided into 4 groups: control group (C), diabetic group (D), diabetic group + c-kit⁺ cell (Dia-c-kit⁺), and diabetic group + c- cell kit- (Dia-c-kit-). In addition, 10 Wistar rats were used to extract stem cells from femur bone marrow. 60 days after the injection, the pathological changes and the levels of MDA, SOD, and GPX were examined in the lung tissue. Results: The results of this study showed that the induction of type 2 diabetes caused pathological changes, increased MDA levels, and decreased SOD and GPX levels in the lung tissue. While, injection of c-kit+ cells had potential to inhibit diabetes-induced changes.