The Evaluation of Prenatal Ultrasound Findings and Their Association with Laboratory Findings in Children with Central Nervous System Disorders

Abstract

Prenatal care is one the fundamentals in pregnancy which has a huge impact on newborns health. Most of the infantile disorders can be recognized prenatally, and therefore provides us an opportunity to affect the frequency of these disorders. CNS malformations are one of the most common disorders during infancy which can be assessed via imaging and laboratory measures. Taking all these into consideration, evaluation of fetuses via imaging modalities like ultrasonography and their association with laboratory findings is essential for detecting antenatal CNS malformations. Methods: In this study, children aged below 15 years old, suffering from CNS disorders, admitted to Tabriz kodakan hospital from March 2018 to March 2020 were evaluated. Exclusion criteria was any hereditary, cardiovascular, neoplastic, or infectious disease except for CNS malformations. After recording demographic information, sonographic and laboratory data were assembled through phone interviews. And collected data were analyzed statistically. Results: Laboratory findings were in normal range in all groups and individuals. There was no significant difference between sonographic results in various CNS disorders(hydrocephalus, spina bifida, dandy walker). Statistical analysis showed significant association between positive imaging result and severity of CNS malformations.