Effect of premedication with oral clonidine on bleeding rate in lumbar laminectomy with pedicular screw

Abstract

Spinal fusion surgery is often associated with major blood loss, decreasing bleeding is important to maintain a patient’s hemodynamic stability and improve the surgical field, decreased bleeding also reduces the need for the transfusion of blood products, thereby reducing the risk of complications, such as hemolytic and non-hemolytic reactions, acute lung injury, transmission of viral and bacterial infections, hypothermia, and coagulation disorders. Therefore, controlling bleeding with techniques and prodrugs in patients during surgery fusion is one of the goals of anesthesia management. The aim of this study was to evaluate the effect of oral clonidine on the bleeding rate of patients undergoing in lumbar laminectomy with pedicular screw. Methods: Patients in operation room of Imam Reza hospital will be randomly divided into two groups according to the random number table. The intervention group received 0.25 mg clonidine and the control group received the same amount of placebo half an hour before surgery. The patient's hemodynamic status, blood loos and complications during and after surgery was recorded The collected data were analyzed by SPSS software version of Windows 22.

Results: The results of the study showed that in the clonidine group the amount of systolic pressure (SBP) and diastolic pressure (DBP) and mean arterial pressure (MAP) heart rate (HR), blood loss, need for blood transfusion and remifentanil dose administered in the clonidine group were significantly lower than the control group and also the surgeon's satisfaction was higher in the clonidine group and was significantly different from the control group.