The effect of seven-strain probiotic supplementation on prooxidant-antioxidant balance, Icam-1 and Vcam-1 in patients with head trauma admitted to intensive care unit: a randomized controlled clinical trial

Abstract

E, C and zinc, copper, and selenium) and dietary fiber were assessed at the beginning and end of the intervention. Results: Of the total 48 patients who entered the study, 40 completed the trial. The results showed that probiotic supplementation for 14 days significantly improves the intake of energy and micronutrients and increases patients' tolerance. Nevertheless, probiotics revealed no significant effect on anthropometric measures. Furthermore, significant reductions were found in serum levels of PAB (P =0.047), ICAM-1 (P =0.002), and VCAM-1 (P =0.003) in the probiotic group. However, after controlling the potential confounders, the changes were not significant. Conclusion: Our findings show that probiotic supplements can be considered an adjuvant supplement in treating TBI by improving inflammation, oxidative stress, and nutritional intake. Keywords: Probiotic, Traumatic brain injury, Inflammatory factors, Oxidative stress