The effect of bone marrow derived c-kit+ cells on lung inflammation and expersion of IL-4, IFN-γ and IL-10 genes in lung tissues of chronic asthmatic male rats

Abstract

Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) which leads to neurodegenerative state. Cerebral small vessel disease (SVD) is an umbrella term Indicating a group of abnormalities related to small blood vessels of the brain. We decided to investigate and compare the distribution of WMHs in MS and SVD in this study. Method: Patients with definite diagnosis of MS and SVD who were referred by a specialist for follow-up with MRI imaging were included in the study. Considering all inclusion and exclusion criteria, 98 MS and 100 SVD patients were included in the study. Among demographic feature, age and sex of all patients were collected. All patients undergone MRI imaging of whole brain. T1-weighted, T2-weighted, DWI/ADC, and FLAIR sequences were used. Only the number of lesions were investigated. Results; The median age of patients with MS and SVD was 45 (14) and 54 (6), respectively (p < 0.001). No significant difference in sex was found between the two groups (p = 0.155). Involvement of all studied brain regions were higher in MS patients and the difference between the two groups was statistically significant in all regions (p < 0.05) except paraventricular and frontal horn of lateral ventricle areas (p = 0.089 & p = 0.163, respectively). The most common form of brain involvement in MS and SVD patients was paraventricular