Effect of oxidant and antioxidant balance on one-year prognosis of acute ischemic stroke patients

Abstract

Oxidative stress is caused by an imbalance in redox-oxidation during which free radicals increase and lead to tissue damage.Oxidative stress is known as one of the effective factors in strokeOn the other hand, stroke has been shown to cause a cascade of events by disrupting the supply of oxygen and nutrients to the brain, which ultimately leads to the production and release of reactive oxygen species (ROS) and the production of oxygen free radicals (oxidants). Materials and methods: Patients with acute ischemic stroke who are eligible for inclusion in the study, after examination and confirmation of the diagnosis of ischemic stroke, patients were included in the study and blood samples were taken to determine malondialdehyde and total antioxidant capacityThese patients were also evaluated by NIHSS and MRS criteria within the first 48 hours after admission.The evaluation was repeated by NIHSS one year later and MRS at the time of discharge and then one year later.During the same period, individuals in the study control groups were examined and sampled for oxidative and antioxidant markers. Results: The results of this study showed that plasma MDA levels were significantly higher in patients with stroke compared to healthy individuals (2.08 24 0.24 vs1.85 36 0.36, 0.001)P <0) was not significantly different from the healthy group in patients with plasma TAC levels (P = 0.46)On the other hand, due to the importance of one-year evaluations performed by MRS and NIHSS scales, it was observed that this relationship is significant only in one-year follow-up of MRS with serum MDA level (P = 0.04).